Browsing by Title
Now showing items 1465-1484 of 1629
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The synthesis and in vitro evaluation of short interfering RNAs that contain internal modified alkyl spacers
(2014-08-01)The ability to silence genes effectively at the pre-translational level through the use of short interfering ribonucleic acid (siRNA) has become a widely studied area since the discovery of the RNA interference pathway in ... -
The synthesis and in vitro evaluation of siRNAs modified at the backbone with a novel triazole-based internucleotide linkage and abasic alkyl-chain linkages of varying length
(2013-04-01)For over a decade, the use of double-stranded short interfering RNAs (siRNAs) to silence the expression of genes associated with disease at the translational level has gained much attention. Using a highly conserved ... -
The synthesis and in vivo evaluation of chemically modified siRNAs that contain red-shifted internal azobenzene derivative spacers for selective and tunable photocontrol of activity without UV light
(2021-08-01)Short interfering RNAs (siRNAs) are biopolymers that are used for post-transcriptional gene regulation and act as endogenous defenses against attack from viruses and dsRNA parasites. The siRNA field is making advances for ... -
Synthesis of internal amide bond short interfering RNAs (siRNAs) and investigation of their gene silencing properties
(2012-10-01)Cancer is a leading cause of death worldwide, accounting for around 13% of all death [1]. Traditional cancer therapeutics usually require careful selection of one or more intervention, such as surgery, radiotherapy, and ... -
Synthesis, characterization and biological investigation of self-delivering and modified short interfering RNAs (siRNAs)
(2021-07-01)Aberrant gene expression is a hallmark of disease, so it is of great interest to develop targeted therapies that provide a means to regulate gene expression. The RNA interference pathway serves as a natural defense system ... -
Synthesizing existing evidence and leveraging expert opinions to develop a university, for-profit, and not-for-profit organization partnership model to address health professions education gaps through simulation-based education
(2023-12-01)Healthcare providers in rural and remote (R&R) areas of Canada do not have the same access to skills development and maintenance opportunities as those in urban areas. Simulation-based education (SBE) is an optimal technique ... -
Synthesizing play: exploring the use of artificial intelligence to evaluate game user experience
(2020-03-01)Digital games are a complex interactive medium providing a multitude of different experiences. The field of games user research (GUR) is dedicated to investigating and optimizing user experience in games. Such inquiries ... -
System for evaluating effects of immersion in molten copper chloride salts on corrosion resistant coatings
(2014-12-01)Hydrogen, as one of the best alternative energy carrier candidates, is easier to sustain than fossil fuel. Hydrogen demand has significantly increased as a clean energy carrier. The Cu-Cl cycle is one of the capable ... -
A system framework for non-intrusive monitoring of HMI states for detecting human-in-the-loop error precursors
(2020-04-01)Past industrial accidents suggest that increased automation has had an adverse effect on operator situational awareness (SA) and Human-in-the-Loop (HITL) errors. More so, any current automation is not yet capable of providing ... -
System integration and optimization of copper-chlorine thermochemical cycle with various options for hydrogen production
(2013-08-01)The Copper-Chlorine (Cu-Cl) thermochemical water splitting cycle is one of the most attractive alternative thermochemical cycles for clean hydrogen production due to its lower temperature requirement and better overall ... -
A systematic review examining the effects of mHealth interventions on dietary adherence in patients with cardiovascular diseases
(2022-04-01)A systematic review was conducted to determine if diet-focused mHealth interventions are effective for supporting dietary adherence in patients with cardiovascular disease (CVD), a population where nonadherence is common. ... -
A systematic review of the literature examining the use and application of robots and artificial intelligence for assisted living for persons living with dementia
(2021)Introduction: This review aims to examine how artificial intelligence (AI) and robotic technologies can enhance quality of life (QOL) outcomes in persons living with dementia (PLD). Methods: A systematic literature search ... -
Systems and models for secure fallback authentication
(2018-12-01)Fallback authentication (FA) techniques such as security questions, Email resets, and SMS resets have significant security flaws that easily undermine the primary method of authentication. Security questions have been shown ... -
A systems approach to assessing the sustainability of hybrid community energy systems.
(2014-09-01)The goal to achieve a sustainable society that will endure over the long term is generally regarded as a positive evolutionary course. One of the challenges with this goal is developing a quantitative assessment of the ... -
“Taking a chance and striking out”: an exploration of homelessness, housing pathways, and ‘self-sabotage’
(2022-08-01)Homelessness remains a prevalent social issue in Canada, though limited research has sought to explore the process of transitioning from homelessness to housing. Exits from homelessness are rarely straightforward and are ... -
Tamil mental health system consumers’ views on the utilization of community mental health resources
(2012-04-01)The goal of this study was to examine the views and perspectives of Tamil mental health outpatients and mental health care workers on the impact social activities and social network has on mentally ill patients’ general ... -
TandemTable: Supporting Conversations and Language Learning Using a Multi-Touch Digital Table
(Association for Computing Machinery, 2015-06-03)We present TandemTable, a multi-touch tabletop system designed to break down communication barriers between partners, with a special focus on supporting those who are learning languages. The design was guided by a grounding ... -
TCP congestion control using reinforcement learning
(2022-10-01)TCP, a transport layer protocol which ensures the reliable delivery of information on the network, is the basis of Internet connectivity, with 85% of the worlds Internet traffic being TCP based. TCP however, is slow to ... -
Teachers' views of their technology-focused preservice education program
(2012-04-01)This study explores the effectiveness of a technology-focused preservice education program by interviewing practicing teachers who have graduated from the program. The views of the teachers are examined with reference to ... -
Technological Advancements in Communication
(UOIT, 2009-12-15)