Browsing by Author "Forrester, Sean"
Now showing items 1-14 of 14
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Characterization of the ACC-1 Family of cys-loop ligand gated ion channels from the parasitic nematode Haemonchus contortus.
Habibi, Sarah A. (2020-12-01)Nematode cys-loop ligand-gated ion channels (LGICs) have been extensively studied for decades because of their role in current anthelmintic action and potential as targets for future drugs. Many families of cys loop receptors ... -
An examination of interacting residues in the GABA-gated ion channel UNC-49 within the parasitic nematode Haemonchus contortus
Cochrane, Everett (2017-10-01)Haemonchus contortus is a blood-feeding parasitic nematode that infects ruminant animals around the world, including those with significant economic importance such as cattle, sheep, and goats. UNC-49 is a GABA-gated ... -
Examination of intramolecular interactions between residues of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus
Foster, Josh G. (2016-01-01)Haemonchus contortus is a parasitic nematode known to infect ruminant animals such as sheep, goats and cattle. Despite several different anthelmintic drugs available to control the spread of this infection, H. contortus ... -
Identification and characterization novel of cystine-loop ligand- gated chloride channels from Dirofilaria immitis: pharmacological analysis and novel compound screening
Varley, Sierra (2023-12-01)Dirofilaria immitis, otherwise known as heartworm, is a parasite that infects the hearts of dogs and causes serious health consequences. While preventative treatments are available drug resistance is developing at an ... -
The identification of novel cys-loop receptor genes in Dirofilaria immitis
Nichols, Jennifer S. (2023-10-01)Dirofilaria immitis is a parasitic nematode responsible for canine heartworm disease. Currently, heartworm treatments rely primarily on a single drug class – the macrocyclic lactones – but anthelmintic resistance is emerging. ... -
Immunomodulatory effects of lactic acid bacteria on human intestinal epithelial cells and macrophages in the context of a pro-inflammatory challenge
Cooper, William (2009-09-01)Immunomodulatory effects of lactic acid bacteria vary with strain and may vary with growth phase and medium. The ability of different lactobacilli strains (Lactobacillus helveticus R0052, L. rhamnosus R0011, L. rhamnosus ... -
Investigation into potential Dirofilaria immitis drug targets through rational anthelmintic synthesis and design
Collins, Autumn M. (2022-04-01)Dirofilaria immitis is a mosquito-transmitted parasitic nematode that can cause debilitating disease in dogs. D. immitis is present in Canada and over the years has increased in prevalence due to several factors including ... -
Investigation into the role of binding loop E on the function of the nematode cys-loop GABA receptor.
Kwaka, Ariel Deborah (2014-12-01)Haemonchus contortus is a parasitic nematode that infects the abomasum of ruminants. While several classes of anthelmintic drugs exist to control nematode infections, H. contortus is resistant to all of them. Therefore, ... -
Isolation and partial characterization of three acetylcholine-gated chloride channels in Haemonchus contortus
Callanan, Micah (2017-01-01)Haemonchus contortus is a parasitic nematode infecting ruminants causing anemia and poor health due to the parasite’s blood-feeding nature. The ability to manage infection has been confounded by the rapid development of ... -
Isolation and partial characterization of three members of the GGR-1 family in the parasitic nematode Haemonchus contortus
Nazareth, Kristen (2019-08-01)Haemonchus contortus is a blood sucking parasitic nematode that infects ruminant animals. These parasites are of significant economic importance as they are estimated to cost the agricultural industry billions of dollars ... -
A molecular characterization of agonists that bind to Hco-UNC-49, a GABA-gated chloride channel from Haemonchus contortus
Kaji, Mark (2012-11-01)Haemonchus contortus is a blood feeding parasitic nematode infecting ruminants causing anemia and poor health at great economic cost. The ability to pharmaceutically control infection has been challenged by the rapid ... -
Molecular characterization of GABA receptor subunits from the parasitic nematode Haemonchus contortus
Siddiqui, Salma (2009-08-01)Haemonchus contortus is a parasitic nematode that is controlled by several nematocides which target ion channels. We have identified two H. contortus ion channel genes, Hcounc- 49B and C that encode two GABA-gated chloride ... -
Molecular characterization of the binding site of nematode GABA-A receptors
Accardi, Michael (2010-08-01)Haemonchus contortus is a parasitic nematode that is controlled in large part by nematocidal drugs that target receptors of the parasitic nervous system. Hco-UNC-49 is a nematode GABA receptor that has a relatively low ... -
The Pharmacological Characterization of Hco-UNC-49, a GABA-gated Chloride Channel from the Parasitic Nematode Haemonchus contortus
Brown, David (2010-08-01)Compared to mammals, nematodes appear to exhibit a unique GABAergic nervous system. Haemonchus controtus is a parasitic nematode that infects ruminants worldwide. Hco-UNC-49 is a H. contortus GABA-gated chloride channel ...