Browsing by Author "Varley, Andrew James"
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Development and characterization of chemical modifications for siRNA strand selection
Varley, Andrew James (2021-12-01)Small interfering RNA (siRNA) are non-coding, double-stranded RNA that enable efficient gene silencing through RNA interference (RNAi) mechanisms. The primary effector of RNAi is an RNA-guided nuclease, Ago2, which selects ... -
The transcription factor, fixK, plays a central role in carbon source metabolism and cellulose synthesis in Komagataeibacter species
Varley, Andrew James (2017-07-01)Komagataeibacter xylinus ATCC 53582 and K. hansenii ATCC 23769 are model bacterial cellulose producers. This thesis investigated both carbon source utilization and the role that a Crp/Fnr transcription factor, FixK, plays ...