Browsing by Subject "UNC-49"
Now showing items 1-3 of 3
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An examination of interacting residues in the GABA-gated ion channel UNC-49 within the parasitic nematode Haemonchus contortus
(2017-10-01)Haemonchus contortus is a blood-feeding parasitic nematode that infects ruminant animals around the world, including those with significant economic importance such as cattle, sheep, and goats. UNC-49 is a GABA-gated ... -
Identification and characterization novel of cystine-loop ligand- gated chloride channels from Dirofilaria immitis: pharmacological analysis and novel compound screening
(2023-12-01)Dirofilaria immitis, otherwise known as heartworm, is a parasite that infects the hearts of dogs and causes serious health consequences. While preventative treatments are available drug resistance is developing at an ... -
The Pharmacological Characterization of Hco-UNC-49, a GABA-gated Chloride Channel from the Parasitic Nematode Haemonchus contortus
(2010-08-01)Compared to mammals, nematodes appear to exhibit a unique GABAergic nervous system. Haemonchus controtus is a parasitic nematode that infects ruminants worldwide. Hco-UNC-49 is a H. contortus GABA-gated chloride channel ...