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Development and characterization of chemical modifications for siRNA strand selection
(2021-12-01)
Small interfering RNA (siRNA) are non-coding, double-stranded RNA that enable efficient gene silencing through RNA interference (RNAi) mechanisms. The primary effector of RNAi is an RNA-guided nuclease, Ago2, which selects ...
On deep learning in physics
(2021-04-01)
Machine learning, and most notably deep neural networks, have seen unprecedented success in recent years due to their ability to learn complex nonlinear mappings by ingesting large amounts of data through the process of ...
Immunomodulatory activity of Lacticaseibacillus rhamnosus R0011: analysis of secretome-mediated impacts on innate immune outcomes in intestinal epithelial cells and antigen presenting cells
(2021-12-01)
Certain lactic acid bacteria (LAB), such as Lacticaseibacillus rhamnosus R0011, are associated with immune modulatory activities including down-regulation of pro-inflammatory gene transcription and expression. While host ...
A deep learning approach to focal cortical dysplasia segmentation in children with medically intractable epilepsy
(2021-08-01)
Paediatric epilepsy is one of the most common neurological disorders and has major impact on the cognition and quality of life of children. Focal Cortical Dysplasia (FCD) is one of the most common causes of medically ...
Monolayer terpyridyl metal complexes for high-efficiency electrochromic materials
(2021-08-01)
Electrochromic materials (ECMs) can change their color with changes of applied electrochemical potential. Currently, the use of ECMs in the industry is limited to mainly inorganic metal oxides, conjugated conducting polymers, ...
Towards molecular reconstruction in Coulomb explosion imaging
(2021-02-01)
The interaction of a fast laser with molecules at the femtosecond time scale, leads to the latter losing most of its valence electrons and become positively charged. The molecule which was initially in an equilibrium state, ...
The synthesis and in vivo evaluation of chemically modified siRNAs that contain red-shifted internal azobenzene derivative spacers for selective and tunable photocontrol of activity without UV light
(2021-08-01)
Short interfering RNAs (siRNAs) are biopolymers that are used for post-transcriptional gene regulation and act as endogenous defenses against attack from viruses and dsRNA parasites. The siRNA field is making advances for ...
Computational methods for medical image registration
(2021-04-01)
A significant amount of research has been dedicated to the improvement of techniques in the field of medical image analysis. Imaging modalities have been improved and new acquisition methods have been introduced to reveal ...
Investigating the distribution of Nitellopsis obtusa in Ontario Lakes and its role as an ecosystem engineer
(2021-08-01)
Nitellopsis obtusa is a non-native macrophyte introduced into the Laurentian Great Lakes in 1974. Over the last decade, increasing reports emerged for N. obtusa within lakes in the Great Lakes Basin. Despite N. obtusa being ...
A modular interface framework for multimodal annotations and visualizations in Human-AI collaboration
(2021-07-01)
Modular is a web-based annotation, visualization, and inference software plat-form for computational language and vision research. The platform enables researchers to set up an interface for efficiently annotating language ...