Doctoral Dissertations: Recent submissions
Now showing items 21-40 of 69
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The synthesis and in vivo evaluation of chemically modified siRNAs that contain red-shifted internal azobenzene derivative spacers for selective and tunable photocontrol of activity without UV light
(2021-08-01)Short interfering RNAs (siRNAs) are biopolymers that are used for post-transcriptional gene regulation and act as endogenous defenses against attack from viruses and dsRNA parasites. The siRNA field is making advances for ... -
Computational methods for medical image registration
(2021-04-01)A significant amount of research has been dedicated to the improvement of techniques in the field of medical image analysis. Imaging modalities have been improved and new acquisition methods have been introduced to reveal ... -
On deep learning in physics
(2021-04-01)Machine learning, and most notably deep neural networks, have seen unprecedented success in recent years due to their ability to learn complex nonlinear mappings by ingesting large amounts of data through the process of ... -
A mixed-method approach to analyze the robustness of natural language processing classifiers
(2021-04-01)Natural language processing algorithms (NLP) have become an essential approach for processing large amounts of textual information with applications such as spam, phishing and content moderation. Malicious actors can craft ... -
Towards molecular reconstruction in Coulomb explosion imaging
(2021-02-01)The interaction of a fast laser with molecules at the femtosecond time scale, leads to the latter losing most of its valence electrons and become positively charged. The molecule which was initially in an equilibrium state, ... -
Adaptive serious games for computer science education
(2020-10-01)Serious games have the potential to effectively engage students to learn, however, these games tend to struggle accommodating learners with diverse abilities and needs. Furthermore, customizing a serious game to the ... -
Development of Non-covalent Chemical Probes for μ, δ and κ Opioid Receptors
(2020-12-01)Opioids are well-known pain relievers and one of several therapeutic options for pain management. Although opioids are very effective analgesics, continued use and abuse can lead to physical dependence and withdrawal ... -
Characterization of the ACC-1 Family of cys-loop ligand gated ion channels from the parasitic nematode Haemonchus contortus.
(2020-12-01)Nematode cys-loop ligand-gated ion channels (LGICs) have been extensively studied for decades because of their role in current anthelmintic action and potential as targets for future drugs. Many families of cys loop receptors ... -
Water quality and biotic community response to an urban – rural land-use gradient in the Lake Simcoe watershed
(2020-06-01)Most research in the Lake Simcoe watershed (LSW) has focused on how the lake has responded to changes in nutrients sourced by agriculture, particularly after mitigation measures have been put in place to remedy the lake’s ... -
Muscle fatigue and other factors influencing forearm muscle activity
(2020-08-01)The wrist extensor muscles of the forearm exhibit relatively greater muscle activity than the wrist flexors during most hand/wrist tasks. Since the extensors operate at a greater percentage of maximum to balance wrist joint ... -
Forward screening for herbicide resistance in Arabidopsis thaliana and the monocot species Triticum aestivum
(2019-06-01)Cellulose is the primary structural component of plant cell walls and is composed of β-1,4-glucan chains. The cellulose synthesis complex is composed of multiple cellulose synthases (CESAs), which work together to extend ... -
Comparing exercise responses to high intensity interval training between adults with and without asthma
(2020-06-01)Exercise induced bronchoconstriction (EIBC) occurs in response to high ventilations during exercise, which cools and dries the airways, triggering an inflammatory cascade. High intensity interval training (HIIT) is associated ... -
A method to detect and represent temporal patterns from time series data and its application for analysis of physiological data streams
(2020-03-01)In critical care, complex systems and sensors continuously monitor patients’ physiological features such as heart rate, respiratory rate thus generating significant amounts of data every second. This results to more than ... -
A graph-based real-time spatial sound framework
(2020-01-01)Given the importance of sound, and our ability to localize sound sources in three-dimensions in the real world, incorporating spatial sound in virtual environments can help increase realism, improve the sense of “presence”, ... -
An anomaly detection model utilizing attributes of low powered networks, IEEE 802.15.4e/TSCH and machine learning methods
(2019-12-01)The rapid growth in sensors, low-power integrated circuits, and wireless communication standards has enabled a new generation of applications based on ultra-low powered wireless sensor networks. These are employed in many ... -
The Effects of 17α-Ethinylestradiol (EE2) and Hydroxypropyl-β-Cyclodextrin (HPβCD) on the heart rate and metabolism of Embryonic Japanese Medaka (Oryzias latipes)
(2019-04-01)Estrogen toxicity has been an area of priority in aquatic toxicology over the last 20 years. The toxicity of a known estrogen mimic, 17α-ethinylestradiol (EE2), has been attributed to classical estrogen signaling within ... -
A study of password recall, perceived memorability, and strength using BCIs
(2018-04-01)Passwords are considered the most common method of authentication and studies are frequently conducted to understand users' password habits. In this thesis, we run two empirical studies that provide information to further ... -
Visual encoding quality and scalability in information visualization
(2019-02-01)Information visualization seeks to amplify cognition through interactive visual representations of data. It comprises human processes, such as perception and cognition, and computer processes, such as visual encoding. ... -
Towards implicit learning of system-assigned authentication tokens
(2018-02-01)People tend to choose predictable passwords which are vulnerable to guessing attacks. To combat the security issue, system-assigned authentication keys were proposed, but coming at a cost to memorability. In this thesis, ... -
Cognitive function during exertional heat stress assessed using traditional and serious game technology
(2016-06-01)Firefighting is a physically demanding occupation requiring intermittent bouts of work resulting in increased levels of cardiovascular and thermal strain, while making decisions requiring higher order cognitive abilities ...