Browsing Faculty of Science by Title
Now showing items 364-383 of 423
-
The synthesis and in vitro evaluation of chemically modified siRNAs that contain internal azobenzene derivative spacers for selective and tunable photocontrol of activity
(2017-08-01)Short interfering RNAs (siRNAs) are biopolymers that are used as post-transcriptional gene regulators and as a natural endogenous defense against attack from viruses. These molecules hold a great deal of interest as ... -
The synthesis and in vitro evaluation of short interfering RNA containing triazole functionalized sphingolipid-based derivatives
(2021-12-01)RNA Interference (RNAi) is a natural cellular process that silences the expression of a target gene in a sequence-specific manner by mediating targeted mRNA degradation. One of the main challenges in RNAi research is ... -
The synthesis and in vitro evaluation of short interfering RNAs that contain internal modified alkyl spacers
(2014-08-01)The ability to silence genes effectively at the pre-translational level through the use of short interfering ribonucleic acid (siRNA) has become a widely studied area since the discovery of the RNA interference pathway in ... -
The synthesis and in vitro evaluation of siRNAs modified at the backbone with a novel triazole-based internucleotide linkage and abasic alkyl-chain linkages of varying length
(2013-04-01)For over a decade, the use of double-stranded short interfering RNAs (siRNAs) to silence the expression of genes associated with disease at the translational level has gained much attention. Using a highly conserved ... -
The synthesis and in vivo evaluation of chemically modified siRNAs that contain red-shifted internal azobenzene derivative spacers for selective and tunable photocontrol of activity without UV light
(2021-08-01)Short interfering RNAs (siRNAs) are biopolymers that are used for post-transcriptional gene regulation and act as endogenous defenses against attack from viruses and dsRNA parasites. The siRNA field is making advances for ... -
Synthesis of internal amide bond short interfering RNAs (siRNAs) and investigation of their gene silencing properties
(2012-10-01)Cancer is a leading cause of death worldwide, accounting for around 13% of all death [1]. Traditional cancer therapeutics usually require careful selection of one or more intervention, such as surgery, radiotherapy, and ... -
Synthesis, characterization and biological investigation of self-delivering and modified short interfering RNAs (siRNAs)
(2021-07-01)Aberrant gene expression is a hallmark of disease, so it is of great interest to develop targeted therapies that provide a means to regulate gene expression. The RNA interference pathway serves as a natural defense system ... -
Synthesizing play: exploring the use of artificial intelligence to evaluate game user experience
(2020-03-01)Digital games are a complex interactive medium providing a multitude of different experiences. The field of games user research (GUR) is dedicated to investigating and optimizing user experience in games. Such inquiries ... -
TandemTable: Supporting Conversations and Language Learning Using a Multi-Touch Digital Table
(Association for Computing Machinery, 2015-06-03)We present TandemTable, a multi-touch tabletop system designed to break down communication barriers between partners, with a special focus on supporting those who are learning languages. The design was guided by a grounding ... -
TCP congestion control using reinforcement learning
(2022-10-01)TCP, a transport layer protocol which ensures the reliable delivery of information on the network, is the basis of Internet connectivity, with 85% of the worlds Internet traffic being TCP based. TCP however, is slow to ... -
Temperature dependent structural, electronic and optical properties of the Si(100) surface from first principles
(2019-04-01)The results presented here were obtained using the local density approximation (LDA) to density functional theory (DFT), within the pseudo-potentials scheme. We present the results of the numerical simulations for the Si ... -
Templated N-doped carbon materials for energy storage and conversion: synthesis and characterization studies
(2020-08-01)Sustainable energy sources are necessary to decrease the environmental problems associated with fossil fuels. Modified mesoporous carbon materials have been studied with aims of improving the performance of energy conversion ... -
Textension: Digitally Augmenting Document Spaces in Analog Texts
(DHQ, 2019)In this paper, we present a system that automatically adds visualizations and natural language processing applications to analog texts, using any web-based device with a camera. After taking a picture of a particular page ... -
Tied In Knots: A Case Study on Anthropographic Data Visualization About Sexual Harassment in the Academy
(IEEE, 2020-10-30)With this pictorial we present the design process of “The Academia is Tied in Knots”, an interactive visualization based on sensitive and qualitative data, namely personal stories reported by people who have experienced ... -
Topic models for image localization
(2013-08-01)We present a new scheme for partitioning geo-tagged reference image database in an effort to speed up query image localization while maintaining acceptable localization accuracy. Our method learns a topic model over the ... -
Total knee replacement serious game for surgical education and training
(2012-08-01)Traditionally, orthopaedic surgical training has primarily taken place in the operating room. Given the growing trend of decreasing resident work hours in North America and globally due to political mandate, training time ... -
Toward graph layout of large data visualization: algorithms, evaluations and application
(2016-01-01)Generating layouts for millions of points on a spatially-restricted platform is a difficult task with a unique set of constraints. These layouts are traditionally generated on a server out of sight of the user. User-oriented ... -
Towards a computational model of information trust
(2022-02-01)Information has been an essential element in the development of collaborative and cooperative frameworks. From decision making to the attainment of different goals, people have been relatively adept at making judgments ... -
Towards a concurrent implementation of keyword search over relational databases.
(2014-06-01)Vast amounts of data are stored in relational databases. Traditionally, querying this data required a deep understanding of the underlying schema in addition to knowledge of a query language such as structured query language ... -
Towards deep learning models for automatic computer program grading
(2023-04-01)Automatic grading of computer programs has a great impact on both computer science education and the software industry as it saves human evaluators a tremendous amount of time required for assessing programs. However, to ...