Browsing Faculty of Science by Author "Bolshan, Yuri"
Now showing items 1-6 of 6
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Brønsted acid-catalyzed reaction of alkynyltrifluoroborates with acetals and ketals
Baxter, Matthew (2015-04-01)The synthesis of small molecules is crucial in the pharmaceutical industry for producing drugs or biologically active compounds. Specifically, the formation of new carbon-carbon bonds is of great importance in synthetic ... -
Brønsted Acid-Catalyzed Reactions of Vinylboronic Acids and Benzhydryl Alcohols
Barichello, Renata Olivia (2020-04-01)The functionalization of benzhydryl alcohols is an approach to form important building blocks in organic synthesis. More specifically, the derivatization of benzhydryl alcohols to afford an alkene is a desired approach due ... -
Brønsted acid-catalyzed stereoselective allylation of exo-glycals with allyltrimethylsilane
Patel, Omik (2022-08-01)Quaternary stereocenter on carbohydrate scaffolds is an important motif due to its presence in natural products and biologically active compounds. However, the preparation of C,C-glycosides is a challenge, and to date, ... -
Development of Non-covalent Chemical Probes for μ, δ and κ Opioid Receptors
Barmaki, Samira (2020-12-01)Opioids are well-known pain relievers and one of several therapeutic options for pain management. Although opioids are very effective analgesics, continued use and abuse can lead to physical dependence and withdrawal ... -
Direct Brønsted acid-catalyzed functionalization of benzhydryl alcohols and 2-ethoxytetrahydrofuran using potassium trifluoroborate salts
Fisher, Kayla M. (2016-06-01)Metal-free transformations of organotrifluoroborates are advantageous since they avoid using frequently expensive and sensitive transition metals. Lewis acid-catalyzed reactions involving organotrifluoroborates have emerged ... -
Metal-free methodology for the preparation of ynones using potassium alkynyltrifluoroborates and its application to the synthesis of natural products
Taylor, Cassandra (2015-03-01)A straightforward procedure for the preparation of ynones from potassium alkynyltrifluoroborate salts and acyl chlorides or anhydrides has been developed. The one-pot reaction is advantageous in that it does not require ...