Browsing Faculty of Science by Author "Simmons, Denina"
Now showing items 1-10 of 10
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Characterizing blood plasma proteins from organ tissue in rainbow trout (Oncorhynchus mykiss) using a non-targeted proteomics approach
Tannouri, Nancy (2021-12-01)Protein expression patterns adapt to various cues to meet the needs of an organism. The dynamicity of an organism’s proteome can therefore reveal information about an organism’s health. Proteome databases contain limited ... -
Determining the differences in effect of chromate, chromite and chromium picolinate in rainbow trout (Oncorhynchus mykiss) at environmentally relevant concentrations
Tudor, Chase R. (2021-11-01)The Ring of Fire is a region in the James Bay Lowlands of northern Ontario that houses a rich deposit of chromite and is slated for mining development. The goals of this study were to better understand the relative effects ... -
Determining the effects of harmful algae blooms and their toxins on fish from both environment and laboratory-based studies through the use of proteomics
Flaherty, Christine M. (2021-01-01)The effects of harmful algae blooms (HABs) on wild, freshwater, large-bodied fish have been under examined. Blood samples were collected from fish in Hamilton Harbor and Lake Erie to assess the effects of HABs on a molecular ... -
Effects of per-and polyfluoroalkyl substances (PFAS) on the freshwater gastropod (Planorbella pilsbryi) in the laboratory and in situ integrating a multi-omic approach
Khan, Almira (2023-09-01)Per- and polyfluoroalkyl substances (PFAS) are anthropogenic chemicals that are globally used in consumer and industrial applications. Specifically, perfluorooctane sulfonate (PFOS) has been under scrutiny due to its ... -
Identifying metabolic indicators of phytoplankton and comparing the temporal changes in algal community composition in two Lake Ontario areas of concern
McNabney, David (2021-12-01)Freshwater algal blooms transition into harmful algal blooms (HABs) when cyanobacteria produce toxins that impact ecosystem health. The point at which algal blooms transition into HABs is not fully understood, but I believe ... -
Investigating proteomic profiles of rainbow trout (oncorhynchus mykiss) kidney and liver tissues exposed to low concentrations of waterborne nickel
Ronnenberg, Kylee (2023-08-01)Nickel has become a component of natural freshwater that may pose serious ecological risks to aquatic wildlife. Due to Canada’s significant presence in producing and exporting nickel, the country has the opportunity to ... -
Investigating proteomic profiles of skin mucus and blood plasma of rainbow trout (Oncorhynchus mykiss) exposed to low concentrations of waterborne nickel
Pajankar, Urvi (2022-08-01)The Ontario Ring of Fire located in the James Bay Lowlands is a nickel rich ore with ongoing mining proposals. This raises the possibility of nickel contamination in one of Ontario’s most precious freshwater regions and ... -
Metabolic, neurotoxic and immunotoxic effects of PFAAs and their mixtures on the proteome of plasma and head kidney from rainbow trout
Pollard, Simon M. (2023-03-01)PFAAs (Perfluoroalkyl acids) are a class of bioaccumulative, persistent and ubiquitous aquatic contaminants. A paucity of toxicological information exists for short chain PFAAs and PFAA mixtures. In order to address these ... -
Refining adverse outcome pathways using Japanese Medaka Embryos (Oryzias latipes) exposed to 2,3,7,8-Tetrachlorodibenzodioxin
Jain, Shreya (2021-08-01)Adverse outcome pathways (AOPs) are a framework that categorizes the impact of chemicals biologically from the initial molecular interaction through to the ecosystem level. This research aims to refine two existing AOPs ... -
Silence of the fish: injection of photoswitchable short interfering RNA oligonucleotides into Japanese medaka embryos (oryzias latipes) to photochemically control gene silencing
Mateus, Makenzie (2023-12-01)The siRNA duplex functions by binding to and cleaving mRNA, a process known as the RNAi pathway. Existing siRNAs face challenges such as off-target effects and unpredictable prolonged gene-silencing. To address these issues, ...