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Molecular characterization of GABA receptor subunits from the parasitic nematode Haemonchus contortus
(2009-08-01)
Haemonchus contortus is a parasitic nematode that is controlled by several nematocides
which target ion channels. We have identified two H. contortus ion channel genes, Hcounc-
49B and C that encode two GABA-gated chloride ...
Molecular characterization of the binding site of nematode GABA-A receptors
(2010-08-01)
Haemonchus contortus is a parasitic nematode that is controlled in large part by
nematocidal drugs that target receptors of the parasitic nervous system. Hco-UNC-49 is a
nematode GABA receptor that has a relatively low ...
Examination of intramolecular interactions between residues of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus
(2016-01-01)
Haemonchus contortus is a parasitic nematode known to infect ruminant animals such as sheep, goats and cattle. Despite several different anthelmintic drugs available to control the spread of this infection, H. contortus ...
An examination of interacting residues in the GABA-gated ion channel UNC-49 within the parasitic nematode Haemonchus contortus
(2017-10-01)
Haemonchus contortus is a blood-feeding parasitic nematode that infects ruminant animals around the world, including those with significant economic importance such as cattle, sheep, and goats. UNC-49 is a GABA-gated ...
Investigation into the role of binding loop E on the function of the nematode cys-loop GABA receptor.
(2014-12-01)
Haemonchus contortus is a parasitic nematode that infects the abomasum of
ruminants. While several classes of anthelmintic drugs exist to control nematode infections,
H. contortus is resistant to all of them. Therefore, ...
Identification and characterization novel of cystine-loop ligand- gated chloride channels from Dirofilaria immitis: pharmacological analysis and novel compound screening
(2023-12-01)
Dirofilaria immitis, otherwise known as heartworm, is a parasite that infects the hearts of dogs and causes serious health consequences. While preventative treatments are available drug resistance is developing at an ...