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An examination of interacting residues in the GABA-gated ion channel UNC-49 within the parasitic nematode Haemonchus contortus
(2017-10-01)
Haemonchus contortus is a blood-feeding parasitic nematode that infects ruminant animals around the world, including those with significant economic importance such as cattle, sheep, and goats. UNC-49 is a GABA-gated ...
Molecular characterization of the binding site of nematode GABA-A receptors
(2010-08-01)
Haemonchus contortus is a parasitic nematode that is controlled in large part by
nematocidal drugs that target receptors of the parasitic nervous system. Hco-UNC-49 is a
nematode GABA receptor that has a relatively low ...
Molecular characterization of GABA receptor subunits from the parasitic nematode Haemonchus contortus
(2009-08-01)
Haemonchus contortus is a parasitic nematode that is controlled by several nematocides
which target ion channels. We have identified two H. contortus ion channel genes, Hcounc-
49B and C that encode two GABA-gated chloride ...
Investigation into the role of binding loop E on the function of the nematode cys-loop GABA receptor.
(2014-12-01)
Haemonchus contortus is a parasitic nematode that infects the abomasum of
ruminants. While several classes of anthelmintic drugs exist to control nematode infections,
H. contortus is resistant to all of them. Therefore, ...