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Synthesis and in vitro assessment of chemically modified siRNAs targeting BCL2 that contain 2'-ribose and triazole-linked backbone modifications
(2015-08-01)
Short interfering RNAs (siRNAs) are biomolecules used for post-transcriptional gene regulation, and therefore hold promise as a future therapeutic by silencing gene expression of overexpressed deleterious genes. Chemically ...