Browsing Master Theses & Projects by Author "Desaulniers, Jean-Paul"
Now showing items 1-7 of 7
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The conjugation and evaluation of hydrophobic small molecules to trazole-linked siRNAs
Peel, Brandon (2014-08-01)According to the Human Development Index, it is estimated that all cancer cases will rise from 12.7 million cases in 2008 to 22.2 million by 2030. Traditional therapies, including surgery, radiation therapy, and chemotherapy, ... -
Investigation into potential Dirofilaria immitis drug targets through rational anthelmintic synthesis and design
Collins, Autumn M. (2022-04-01)Dirofilaria immitis is a mosquito-transmitted parasitic nematode that can cause debilitating disease in dogs. D. immitis is present in Canada and over the years has increased in prevalence due to several factors including ... -
Silence of the fish: injection of photoswitchable short interfering RNA oligonucleotides into Japanese medaka embryos (oryzias latipes) to photochemically control gene silencing
Mateus, Makenzie (2023-12-01)The siRNA duplex functions by binding to and cleaving mRNA, a process known as the RNAi pathway. Existing siRNAs face challenges such as off-target effects and unpredictable prolonged gene-silencing. To address these issues, ... -
Synthesis and in vitro assessment of chemically modified siRNAs targeting BCL2 that contain 2'-ribose and triazole-linked backbone modifications
Hagen, Gordon (2015-08-01)Short interfering RNAs (siRNAs) are biomolecules used for post-transcriptional gene regulation, and therefore hold promise as a future therapeutic by silencing gene expression of overexpressed deleterious genes. Chemically ... -
The synthesis and in vitro evaluation of chemically modified siRNAs that contain internal azobenzene derivative spacers for selective and tunable photocontrol of activity
Hammill, Matthew (2017-08-01)Short interfering RNAs (siRNAs) are biopolymers that are used as post-transcriptional gene regulators and as a natural endogenous defense against attack from viruses. These molecules hold a great deal of interest as ... -
The synthesis and in vitro evaluation of short interfering RNA containing triazole functionalized sphingolipid-based derivatives
Fernandez, Charlene A. (2021-12-01)RNA Interference (RNAi) is a natural cellular process that silences the expression of a target gene in a sequence-specific manner by mediating targeted mRNA degradation. One of the main challenges in RNAi research is ... -
The synthesis and in vitro evaluation of short interfering RNAs that contain internal modified alkyl spacers
McKim, Christopher J. (2014-08-01)The ability to silence genes effectively at the pre-translational level through the use of short interfering ribonucleic acid (siRNA) has become a widely studied area since the discovery of the RNA interference pathway in ...