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Synthesis and in vitro assessment of chemically modified siRNAs targeting BCL2 that contain 2'-ribose and triazole-linked backbone modifications
(2015-08-01)
Short interfering RNAs (siRNAs) are biomolecules used for post-transcriptional gene regulation, and therefore hold promise as a future therapeutic by silencing gene expression of overexpressed deleterious genes. Chemically ...
The synthesis and in vitro evaluation of short interfering RNA containing triazole functionalized sphingolipid-based derivatives
(2021-12-01)
RNA Interference (RNAi) is a natural cellular process that silences the expression of a target gene in a sequence-specific manner by mediating targeted mRNA degradation. One of the main challenges in RNAi research is ...
The synthesis and in vitro evaluation of short interfering RNAs that contain internal modified alkyl spacers
(2014-08-01)
The ability to silence genes effectively at the pre-translational level through the use of short interfering ribonucleic acid (siRNA) has become a widely studied area since the discovery of the RNA interference pathway in ...
The synthesis and in vitro evaluation of chemically modified siRNAs that contain internal azobenzene derivative spacers for selective and tunable photocontrol of activity
(2017-08-01)
Short interfering RNAs (siRNAs) are biopolymers that are used as post-transcriptional gene regulators and as a natural endogenous defense against attack from viruses. These molecules hold a great deal of interest as ...
Silence of the fish: injection of photoswitchable short interfering RNA oligonucleotides into Japanese medaka embryos (oryzias latipes) to photochemically control gene silencing
(2023-12-01)
The siRNA duplex functions by binding to and cleaving mRNA, a process known as the RNAi pathway. Existing siRNAs face challenges such as off-target effects and unpredictable prolonged gene-silencing. To address these issues, ...