Browsing Doctoral Dissertations by Issue Date
Now showing items 41-60 of 71
-
Water quality and biotic community response to an urban – rural land-use gradient in the Lake Simcoe watershed
(2020-06-01)Most research in the Lake Simcoe watershed (LSW) has focused on how the lake has responded to changes in nutrients sourced by agriculture, particularly after mitigation measures have been put in place to remedy the lake’s ... -
Comparing exercise responses to high intensity interval training between adults with and without asthma
(2020-06-01)Exercise induced bronchoconstriction (EIBC) occurs in response to high ventilations during exercise, which cools and dries the airways, triggering an inflammatory cascade. High intensity interval training (HIIT) is associated ... -
Muscle fatigue and other factors influencing forearm muscle activity
(2020-08-01)The wrist extensor muscles of the forearm exhibit relatively greater muscle activity than the wrist flexors during most hand/wrist tasks. Since the extensors operate at a greater percentage of maximum to balance wrist joint ... -
Adaptive serious games for computer science education
(2020-10-01)Serious games have the potential to effectively engage students to learn, however, these games tend to struggle accommodating learners with diverse abilities and needs. Furthermore, customizing a serious game to the ... -
Characterization of the ACC-1 Family of cys-loop ligand gated ion channels from the parasitic nematode Haemonchus contortus.
(2020-12-01)Nematode cys-loop ligand-gated ion channels (LGICs) have been extensively studied for decades because of their role in current anthelmintic action and potential as targets for future drugs. Many families of cys loop receptors ... -
Development of Non-covalent Chemical Probes for μ, δ and κ Opioid Receptors
(2020-12-01)Opioids are well-known pain relievers and one of several therapeutic options for pain management. Although opioids are very effective analgesics, continued use and abuse can lead to physical dependence and withdrawal ... -
Towards molecular reconstruction in Coulomb explosion imaging
(2021-02-01)The interaction of a fast laser with molecules at the femtosecond time scale, leads to the latter losing most of its valence electrons and become positively charged. The molecule which was initially in an equilibrium state, ... -
A mixed-method approach to analyze the robustness of natural language processing classifiers
(2021-04-01)Natural language processing algorithms (NLP) have become an essential approach for processing large amounts of textual information with applications such as spam, phishing and content moderation. Malicious actors can craft ... -
Computational methods for medical image registration
(2021-04-01)A significant amount of research has been dedicated to the improvement of techniques in the field of medical image analysis. Imaging modalities have been improved and new acquisition methods have been introduced to reveal ... -
On deep learning in physics
(2021-04-01)Machine learning, and most notably deep neural networks, have seen unprecedented success in recent years due to their ability to learn complex nonlinear mappings by ingesting large amounts of data through the process of ... -
Forward and reverse genetic approaches to investigate cellulose biosynthesis in Physcomitrium patens
(2021-04-01)Cellulose biosynthesis is a common feature of land plants and involves multimeric complexes composed of cellulose synthase A (CESA) proteins and other structural proteins. The exact stoichiometry of CESA proteins and ... -
A modular interface framework for multimodal annotations and visualizations in Human-AI collaboration
(2021-07-01)Modular is a web-based annotation, visualization, and inference software plat-form for computational language and vision research. The platform enables researchers to set up an interface for efficiently annotating language ... -
Synthesis, characterization and biological investigation of self-delivering and modified short interfering RNAs (siRNAs)
(2021-07-01)Aberrant gene expression is a hallmark of disease, so it is of great interest to develop targeted therapies that provide a means to regulate gene expression. The RNA interference pathway serves as a natural defense system ... -
The synthesis and in vivo evaluation of chemically modified siRNAs that contain red-shifted internal azobenzene derivative spacers for selective and tunable photocontrol of activity without UV light
(2021-08-01)Short interfering RNAs (siRNAs) are biopolymers that are used for post-transcriptional gene regulation and act as endogenous defenses against attack from viruses and dsRNA parasites. The siRNA field is making advances for ... -
Investigating the distribution of Nitellopsis obtusa in Ontario Lakes and its role as an ecosystem engineer
(2021-08-01)Nitellopsis obtusa is a non-native macrophyte introduced into the Laurentian Great Lakes in 1974. Over the last decade, increasing reports emerged for N. obtusa within lakes in the Great Lakes Basin. Despite N. obtusa being ... -
A deep learning approach to focal cortical dysplasia segmentation in children with medically intractable epilepsy
(2021-08-01)Paediatric epilepsy is one of the most common neurological disorders and has major impact on the cognition and quality of life of children. Focal Cortical Dysplasia (FCD) is one of the most common causes of medically ... -
Monolayer terpyridyl metal complexes for high-efficiency electrochromic materials
(2021-08-01)Electrochromic materials (ECMs) can change their color with changes of applied electrochemical potential. Currently, the use of ECMs in the industry is limited to mainly inorganic metal oxides, conjugated conducting polymers, ... -
Immunomodulatory activity of Lacticaseibacillus rhamnosus R0011: analysis of secretome-mediated impacts on innate immune outcomes in intestinal epithelial cells and antigen presenting cells
(2021-12-01)Certain lactic acid bacteria (LAB), such as Lacticaseibacillus rhamnosus R0011, are associated with immune modulatory activities including down-regulation of pro-inflammatory gene transcription and expression. While host ... -
Development and characterization of chemical modifications for siRNA strand selection
(2021-12-01)Small interfering RNA (siRNA) are non-coding, double-stranded RNA that enable efficient gene silencing through RNA interference (RNAi) mechanisms. The primary effector of RNAi is an RNA-guided nuclease, Ago2, which selects ... -
Towards a computational model of information trust
(2022-02-01)Information has been an essential element in the development of collaborative and cooperative frameworks. From decision making to the attainment of different goals, people have been relatively adept at making judgments ...