Browsing Doctoral Dissertations by Author "Desaulniers, Jean-Paul"
Now showing items 1-5 of 5
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Analysis of the volatile organic compounds produced by the decomposition of pig carcasses and human remains
Stadler, Sonja (2013-03-01)Complex processes of decomposition produce a variety of chemicals as soft tissues and their component parts are degraded. Among others, these decomposition by-products include volatile organic compounds (VOCs) responsible ... -
Development and characterization of chemical modifications for siRNA strand selection
Varley, Andrew James (2021-12-01)Small interfering RNA (siRNA) are non-coding, double-stranded RNA that enable efficient gene silencing through RNA interference (RNAi) mechanisms. The primary effector of RNAi is an RNA-guided nuclease, Ago2, which selects ... -
The synthesis and in vitro evaluation of siRNAs modified at the backbone with a novel triazole-based internucleotide linkage and abasic alkyl-chain linkages of varying length
Efthymiou, Tim (2013-04-01)For over a decade, the use of double-stranded short interfering RNAs (siRNAs) to silence the expression of genes associated with disease at the translational level has gained much attention. Using a highly conserved ... -
The synthesis and in vivo evaluation of chemically modified siRNAs that contain red-shifted internal azobenzene derivative spacers for selective and tunable photocontrol of activity without UV light
Hammill, Matthew (2021-08-01)Short interfering RNAs (siRNAs) are biopolymers that are used for post-transcriptional gene regulation and act as endogenous defenses against attack from viruses and dsRNA parasites. The siRNA field is making advances for ... -
Synthesis, characterization and biological investigation of self-delivering and modified short interfering RNAs (siRNAs)
Salim, Lidya (2021-07-01)Aberrant gene expression is a hallmark of disease, so it is of great interest to develop targeted therapies that provide a means to regulate gene expression. The RNA interference pathway serves as a natural defense system ...