Browsing Doctoral Dissertations by Author "Varley, Andrew James"
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Development and characterization of chemical modifications for siRNA strand selection
Varley, Andrew James (2021-12-01)Small interfering RNA (siRNA) are non-coding, double-stranded RNA that enable efficient gene silencing through RNA interference (RNAi) mechanisms. The primary effector of RNAi is an RNA-guided nuclease, Ago2, which selects ...