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Characterization of the ACC-1 Family of cys-loop ligand gated ion channels from the parasitic nematode Haemonchus contortus.
(2020-12-01)
Nematode cys-loop ligand-gated ion channels (LGICs) have been extensively studied for decades because of their role in current anthelmintic action and potential as targets for future drugs. Many families of cys loop receptors ...
Immunomodulatory activity of Lacticaseibacillus rhamnosus R0011: analysis of secretome-mediated impacts on innate immune outcomes in intestinal epithelial cells and antigen presenting cells
(2021-12-01)
Certain lactic acid bacteria (LAB), such as Lacticaseibacillus rhamnosus R0011, are associated with immune modulatory activities including down-regulation of pro-inflammatory gene transcription and expression. While host ...
Development and characterization of chemical modifications for siRNA strand selection
(2021-12-01)
Small interfering RNA (siRNA) are non-coding, double-stranded RNA that enable efficient gene silencing through RNA interference (RNAi) mechanisms. The primary effector of RNAi is an RNA-guided nuclease, Ago2, which selects ...
Monolayer terpyridyl metal complexes for high-efficiency electrochromic materials
(2021-08-01)
Electrochromic materials (ECMs) can change their color with changes of applied electrochemical potential. Currently, the use of ECMs in the industry is limited to mainly inorganic metal oxides, conjugated conducting polymers, ...
Comparing exercise responses to high intensity interval training between adults with and without asthma
(2020-06-01)
Exercise induced bronchoconstriction (EIBC) occurs in response to high ventilations during exercise, which cools and dries the airways, triggering an inflammatory cascade. High intensity interval training (HIIT) is associated ...
Muscle fatigue and other factors influencing forearm muscle activity
(2020-08-01)
The wrist extensor muscles of the forearm exhibit relatively greater muscle activity than the wrist flexors during most hand/wrist tasks. Since the extensors operate at a greater percentage of maximum to balance wrist joint ...
A graph-based real-time spatial sound framework
(2020-01-01)
Given the importance of sound, and our ability to localize sound sources in three-dimensions in the real world, incorporating spatial sound in virtual environments can help increase realism, improve the sense of “presence”, ...
A method to detect and represent temporal patterns from time series data and its application for analysis of physiological data streams
(2020-03-01)
In critical care, complex systems and sensors continuously monitor patients’ physiological features such as heart rate, respiratory rate thus generating significant amounts of data every second. This results to more than ...
A mixed-method approach to analyze the robustness of natural language processing classifiers
(2021-04-01)
Natural language processing algorithms (NLP) have become an essential approach for processing large amounts of textual information with applications such as spam, phishing and content moderation. Malicious actors can craft ...
The synthesis and in vivo evaluation of chemically modified siRNAs that contain red-shifted internal azobenzene derivative spacers for selective and tunable photocontrol of activity without UV light
(2021-08-01)
Short interfering RNAs (siRNAs) are biopolymers that are used for post-transcriptional gene regulation and act as endogenous defenses against attack from viruses and dsRNA parasites. The siRNA field is making advances for ...