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Development and characterization of chemical modifications for siRNA strand selection
(2021-12-01)
Small interfering RNA (siRNA) are non-coding, double-stranded RNA that enable efficient gene silencing through RNA interference (RNAi) mechanisms. The primary effector of RNAi is an RNA-guided nuclease, Ago2, which selects ...
Approaching Humanities Questions Using Slow Visual Search Interfaces
(2021-06-01)
In this paper we discuss a visual search system that was designed and implemented for humanities scholars to ask questions of large document corpora. The system allows searches to be specified through traditional search, ...
An Online System for Visualizing UOIT Class Schedules
(2021-06-02)
The objective of this thesis is to design a system that will enable users to visualize aspects of a schedule so that the information can be interpreted in a meaningful way. The concept of visualizing data has allowed many ...
Synthesis, characterization and biological investigation of self-delivering and modified short interfering RNAs (siRNAs)
(2021-07-01)
Aberrant gene expression is a hallmark of disease, so it is of great interest to develop targeted therapies that provide a means to regulate gene expression. The RNA interference pathway serves as a natural defense system ...
MAVIDS: an intelligent intrusion detection system for autonomous unmanned aerial vehicles
(2021-07-01)
Unmanned Aerial Vehicles (UAVs) face a large threat landscape, being used in numerous industries in hostile environments while relying on wireless communication. As attacks against UAVs increase, an intelligent Intrusion ...
Forward and reverse genetic approaches to investigate cellulose biosynthesis in Physcomitrium patens
(2021-04-01)
Cellulose biosynthesis is a common feature of land plants and involves multimeric complexes composed of cellulose synthase A (CESA) proteins and other structural proteins. The exact stoichiometry of CESA proteins and ...