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Development and characterization of chemical modifications for siRNA strand selection
(2021-12-01)
Small interfering RNA (siRNA) are non-coding, double-stranded RNA that enable efficient gene silencing through RNA interference (RNAi) mechanisms. The primary effector of RNAi is an RNA-guided nuclease, Ago2, which selects ...
On deep learning in physics
(2021-04-01)
Machine learning, and most notably deep neural networks, have seen unprecedented success in recent years due to their ability to learn complex nonlinear mappings by ingesting large amounts of data through the process of ...
Towards efficient and scalable computer vision systems
(2018-01-01)
There is a large growth in hardware and software systems capable of producing vast amounts of image and video data. These systems are rich sources of continuous and possibly infinite image and video streams. This motivates ...
A graph-based real-time spatial sound framework
(2020-01-01)
Given the importance of sound, and our ability to localize sound sources in three-dimensions in the real world, incorporating spatial sound in virtual environments can help increase realism, improve the sense of “presence”, ...
Towards implicit learning of system-assigned authentication tokens
(2018-02-01)
People tend to choose predictable passwords which are vulnerable to guessing attacks. To combat the security issue, system-assigned authentication keys were proposed, but coming at a cost to memorability. In this thesis, ...
Comparing exercise responses to high intensity interval training between adults with and without asthma
(2020-06-01)
Exercise induced bronchoconstriction (EIBC) occurs in response to high ventilations during exercise, which cools and dries the airways, triggering an inflammatory cascade. High intensity interval training (HIIT) is associated ...
The ecotoxicological effects of metformin and its metabolite, guanylurea, on Japanese medaka (Oryzias latipes)
(2018-08-01)
Human pharmaceutical waste threatens many natural processes of non-target aquatic organisms, through the introduction of such contaminants into the environment. Pharmaceuticals are a large and diverse groups of medicinal ...
The impact of restricted ration and chemical stressors on Rainbow trout (Oncorhynchus mykiss) and American flagfish (Jordanella floridae)
(2017-12-01)
This research aimed to increase the understanding of the impact of multiple factors including both environmental and chemical stressors and their effects on fish survival, growth, and reproduction. Rainbow trout (Oncorhynchus ...
The Effects of 17α-Ethinylestradiol (EE2) and Hydroxypropyl-β-Cyclodextrin (HPβCD) on the heart rate and metabolism of Embryonic Japanese Medaka (Oryzias latipes)
(2019-04-01)
Estrogen toxicity has been an area of priority in aquatic toxicology over the last 20 years. The toxicity of a known estrogen mimic, 17α-ethinylestradiol (EE2), has been attributed to classical estrogen signaling within ...
Alloy catalysts for fuel cell-based alcohol sensors
(2016-05-01)
Direct ethanol fuel cells (DEFCs) are attractive from both economic and environmental standpoints for generating renewable energy and powering vehicles and portable electronic devices. The cost and performance of the DEFCs ...